How to Fight Inflammation Induced Aging

How to Fight Inflammation Induced Aging

Rho Nutrition Rho Nutrition
8 minute read


Aging is inevitable, but can we slow it down or even reverse it? In this article we will

 explore the role of inflammation in aging and age-related diseases, and propose some

novel and practical anti-aging strategies based on inflammation modulation and


What is Inflammaging?

Inflammation is a natural response of the body to injury, infection, or stress. It helps to

eliminate harmful agents and promote healing. However, when inflammation becomes

chronic and systemic, it can have detrimental effects on the body and contribute to

aging and age-related diseases. This phenomenon is called inflammaging 2 .

Inflammaging is characterized by elevated levels of inflammatory factors in the blood

and tissues, such as cytokines, chemokines, reactive oxygen species, and complement

components. These factors can damage the cells and organs, induce cellular

senescence, impair immune function, and promote disease development 1 .

What Causes Inflammaging?

Inflammaging is caused by a complex interplay of various factors, such as genetic,

epigenetic, environmental, metabolic, microbial, hormonal, and immunological factors 1 .

Some of the major causes of inflammaging are:

Cellular senescence:

Senescent cells are cells that have stopped dividing due to

DNA damage, telomere shortening, oxidative stress, or other reasons. Senescent

cells secrete a variety of inflammatory factors, known as the senescence-

associated secretory phenotype (SASP). The secretion of SASP from these

inefficient cells is begins to effect neighboring cells, inducing inflammation one

cell at a time 3 . Eventually, these senescent cells secrete enough SASP to spoil all

of their neighboring cells, leading to severe cellular dysfunction.


Immunosenescence is the decline of immune function with

aging. It is characterized by reduced production and diversity of immune cells,

impaired response to antigens and vaccines, increased susceptibility to

infections and cancers, and chronic low-grade inflammation 4 .

Organ dysfunction:

Chronic inflammation can affect the function and structure of

various organs, such as the bone marrow, liver, lungs, brain, heart, kidneys, skin,

etc. For example:Inflammation can impair hematopoiesis in the bone marrow 5 , leading to

anemia, leukopenia, thrombocytopenia, and immunodeficiency.

  • Inflammation can cause fibrosis in the liver, resulting in cirrhosis, portal

hypertension, hepatic encephalopathy, and liver failure.

  • Inflammation can induce chronic obstructive pulmonary disease in the

lungs, causing airflow limitation, dyspnea, cough, sputum production, and

respiratory infections.

  • Inflammation can promote neurodegeneration in the brain, contributing to

cognitive impairment, dementia, Alzheimer’s disease, Parkinson’s disease,

and stroke.

  • Inflammation can increase cardiovascular risk in the heart, leading to

atherosclerosis, hypertension, coronary artery disease, myocardial

infarction, heart failure, and arrhythmias.

  • Inflammation can impair renal function in the kidneys, causing proteinuria,

hematuria, azotemia, uremia, and chronic kidney disease.

  • Inflammation can accelerate skin aging, causing wrinkles, sagging,

dryness, pigmentation, and skin cancer.

Age-related diseases:

Inflammation is also associated with many age-related

diseases, such as diabetes, obesity, arthritis, osteoporosis, cancer,

etc. Inflammation can both cause and result from these diseases, creating a

vicious cycle of disease progression and aging 1 . For example:

  • In diabetes mellitus, hyperglycemia can induce oxidative stress and

inflammation, which can damage the pancreatic β-cells, impair insulin

secretion and sensitivity, and cause diabetic complications, such as

retinopathy, nephropathy, neuropathy, and cardiovascular disease.

  • In obesity, excess adipose tissue can secrete inflammatory protein

messenger cells called cytokines and chemokines, which can activate that

activate certain biological signaling pathways in various tissues, leading to

insulin resistance, dyslipidemia, hypertension, and metabolic syndrome.

  • In rheumatoid arthritis, autoantibodies (such as rheumatoid factor and

anti-citrullinated protein antibodies) can trigger inflammation in the

synovial joints, causing synovitis, cartilage degradation, bone erosion, joint

deformity, and disability.

  • In osteoporosis, inflammation can stimulate osteoclast differentiation and

activity, leading to increased bone resorption and decreased bone

formation, resulting in low bone mass, fragility fractures, and increased


  • In cancer, inflammation can promote tumor initiation, progression,

invasion, metastasis, angiogenesis, and immune evasion, as well as

resistance to chemotherapy and radiotherapy.

How to regulate inflammation for anti-aging?

Since Inflammation is a key driver of aging and age related diseases, there are 4 basic

strategies to regulate inflammation:

Proactively promote healthy cellular energy production:

Cellular senescence can be initiated by a wide variety of stress factors such as damage to DNA,

mitochondrial damage and environmental damaging events. Improved cellular

energy provides healthy cells with the ability to overcome stress factors and

avoid senescence and the secretion and spread of SASP factors.

Targeting SASP factors or receptors:

SASP factors are responsible for inducing inflammation and senescence in normal cells. By blocking their production or action with specific inhibitors or antibodies, the harmful effects of SASP can be reduced or eliminated.

Enhancing immune surveillance or clearance of senescent cells or inflammatory factors:

Senescent cells and inflammatory factors accumulate with aging and

contribute to inflammaging. By boosting the immune system’s ability to

recognize and eliminate them with immunotherapy or phagocytosis enhancers,

the burden of inflammaging can be alleviated.

Modulating microbiota or metabolites that affect inflammation and aging:

Thegut microbiota plays an important role in modulating inflammation and aging

through its interactions with the host immune system and metabolism. By

manipulating the composition or function of the gut microbiota with probiotics,

prebiotics, synbiotics, or fecal microbiota transplantation, the inflammatory

status and aging process can be influenced.

Three Supplements to Regulate Inflammation for Anti-Aging

  1. NAD (nicotinamide adenine dinucleotide) a coenzyme that participates in

various metabolic reactions in the cells. NAD levels decline greatly after the age

of 30, which can impair cellular energy production, DNA repair, gene expression,

and stress response. NAD is the fuel source of every healthy cell and when NAD

declines so does cellular energy production and the cells ability to overcome

stress factors that lead to senescence. NAD can also enhance immune

surveillance or clearance of senescent cells or inflammatory factors by

increasing the activity of sirtuids which can modulate the function and diversity

of immune cells (such as T cells, B cells) and enhance immune recognition and

elimination of senescent cells or inflammatory cells.

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2. Curcumin is a polyphenol derived from turmeric, a spice commonly used in Asian

cuisine. Curcumin can target SASP factors and receptors by inhibiting the

production and action of pro-inflammatory senescent cell secretions, (cytokines

and chemokines) and that are secreted by inflammatory cells and negatively

impact neighboring cells. Curcumin can also enhance immune surveillance or

clearance of senescent cells or inflammatory factors by activating the Nrf2

pathway, (a metabolic pathway which induces the expression of antioxidant and

detoxifying enzymes that can protect the cells from oxidative stress and

inflammation. These antioxidants combat and neutralize accumulations of

oxidative stress and prevent large scale inflammation. Curcumin can also

modulate microbiota or metabolites that affect inflammation and aging by

altering the composition and function of the gut microbiota, enhancing the

intestinal barrier integrity, reducing the translocation of endotoxins and

pathogens, and producing anti-inflammatory metabolites (such as short-chain

fatty acids) 12 .

3. Resveratrol is a polyphenol found in grapes, red wine, and Japanese knotweed.

Resveratrol can target SASP factors and receptors by inhibiting the activation of

inflammasome pathways, which are responsible for the synthesis and release of

pro-inflammatory cell secretions (cytokines and chemokines) by inflammatory

cells. Resveratrol can also enhance immune surveillance or clearance of

senescent cells or inflammatory factors by activating SIRT1, (a family of proteins

that regulate cellular survival and cellular senescence and that is fueled by

NAD+) Resveratrol can also modulate microbiota or metabolites that affect

inflammation and aging by altering the composition and function of the gut

microbiota, enhancing the intestinal barrier integrity, reducing the translocation

of endotoxins and pathogens, and producing anti-inflammatory metabolites

(such as short-chain fatty acids) 3  .

Liposomal Curcumin + Resveratrol

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Inflammation is a double-edged sword that can be beneficial or harmful depending on

the context and duration. Inflammaging is a chronic and systemic inflammation that

accelerates aging and age-related diseases. By understanding the molecular

mechanisms and cellular dynamics of inflammation and aging, and by developing novel

and practical anti-aging strategies based on inflammation modulation, we may be able

to delay or reverse the aging process and improve the quality of life for the elderly.

1. Li, X., Li, C., Zhang, W. et al. Inflammation and aging: signaling pathways and intervention

therapies. Sig Transduct Target Ther 8, 239 (2023).

2. Campisi, J. et al. From discoveries in ageing research to therapeutics for healthy

ageing. Nature 571, 183–192 (2019).

3 Hagen, M. & Derudder, E. Inflammation and the alteration of B-cell physiology in

aging. Gerontology 66, 105–113 (2020).

4. Yousefzadeh, M. J. et al. An aged immune system drives senescence and ageing of solid

organs. Nature 594, 100–105 (2021).

5. Labrie, J. E. 3rd et al. Bone marrow microenvironmental changes underlie reduced RAG-

mediated recombination and B cell generation in aged mice. J. Exp. Med. 200, 411–423 (2004).

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