NAD IV Therapy: Benefits and Uses, Side Effects, and Alternatives

NAD IV Therapy: Benefits and Uses, Side Effects, and Alternatives

Rho Nutrition Rho Nutrition
13 minute read

What is NAD+?

NAD stands for nicotinamide adenine dinucleotide. It's this molecule that's everywhere, from the simplest bacteria to complex beings like us. Seriously, NAD+ is foundational; without it, our cellular processes would crash. It's central to how our cell 'power stations' – the mitochondria – work. Beyond its role in metabolizing food into energy, NAD+ is vital for DNA integrity. From slowing the aging process and increasing cellular energy levels to promoting healthy brain function, NAD+ has a hand in all biological processes. Essentially, NAD+ acts like quality control, ensuring cells function properly, which, in turn, helps restore cellular health to defend us against age related diseases.

How does NAD+ work?

NADoperates much like a pivotal transporter within our cells, moving electrons between molecules to facilitate numerous reactions and processes. It plays an essential role in almost all of the body's metabolic processes and DNA repair. Without adequate NAD+ levels, our cells would lack the energy required for survival and proper function.

As time progresses and aging ensues, there is a noticeable decline in NAD+ levels. This has profound implications for the human body and the onset of age-related diseases. Common symptoms of lower NAD+ include:

  • Chronic Fatigue Syndrome
  • Poor cognitive function and cognitive decline
  • Slow energy metabolism
  • Decreased athletic performance and muscle function
  • Trouble with weight management
  • Onset of age related illnesses

Benefits of NAD+ and Uses

Research on the effects of NAD within the body is continually evolving. However, a multitude of studies have underscored the multifaceted benefits of NAD supplementation and restoration for various conditions. Here's a comprehensive breakdown:

  • Addiction and Substance Abuse Recovery: NAD+ has been demonstrated in addiction therapy to mitigate withdrawal symptoms and reduce cravings, assisting those on their path to recovery. [1] [2] [3]
  • Anti Aging and Longevity Benefits: Integral to DNA repair, NAD holds promise in its potential to delay the aging process. Its anti-aging effects are well documented and studied in human patients and in living cells.
  • Neurological Function: There's growing evidence that NAD can restore brain function, offering a protective layer against neurological disorders and neurodegenerative diseases.
  • Cognitive Health: From enhancing mental clarity to alleviating memory loss and brain fog, NAD+ offers tangible benefits for those experiencing cognitive impairment by improving cognitive function directly in brain cells for improved brain function.
  • Athletic Performance and Muscle Function: Athletes and fitness enthusiasts can benefit from NAD's ability to bolster muscle function, boost energy levels, and promote healthy metabolism, thereby heightening endurance and overall performance.
  • Weight Loss Support: With its capacity to rev up metabolism and reduce inflammation, NAD+ can be a valuable adjunct to weight loss strategies due to its role in cellular health.
  • Energy Enhancement: By optimizing mitochondrial function, the powerhouses of our cells, NAD+ can markedly boost energy production, combating chronic fatigue.
  • Mental Well-being: NAD's role in brain health also translates to its potential in mitigating symptoms of mood disorders such as anxiety and depression, paving the way for improved mental well-being.

NAD IV Therapy: NAD IV vs NAD Injections:

NAD therapy can be a powerful means of boosting cellular health and addressing various health concerns. Here's a breakdown of the two common modes of NAD+ delivery - intravenous (NAD IV drip) and NAD+ Infusions:

NAD IV Therapy Method

NAD IV therapy delivers NAD+ directly to the bloodstream via IV fluids. A sterile solution containing NAD+ and, at times, other vitamins or supplements, is infused into a vein, typically in the arm by a nurse practitioner.

Pros :

  • Direct Delivery: of the proposed benefits of NAD IV is that it bypasses the digestive system, ensuring that none of the nutrients are lost. Some oral treatments may lose up to 50% of their efficacy due to digestion. This provides an immediate effect given that the nutrients are directly infused into the bloodstream, the effects are almost immediate.

  • Hydration and Detox: IV fluids aid in hydration and toxin elimination, which is particularly beneficial for those undergoing detoxification or recovery from substance abuse.

  • Administered by Professionals: Reduces potential errors or complications.

  • Multi-beneficial: Provides hydration and allows for additional nutrients..


  • Cost: Typically, the most costly mode of NAD treatment $500-$1000 USD on average.

  • Appointment Necessity: Requires scheduled sessions that might span several weeks.

  • Needle Aversion: Not suitable for those with needle phobia.

  • NAD Injections Method: Direct injections of NAD into the bloodstream. It is a quicker, more condensed method than the IV drip. Benefits: Those who wish for direct bloodstream delivery benefits without regular IV appointments might opt for NAD injections.

NAD Injections

Direct injections of NAD+ into the bloodstream. It is a quicker, more condensed method than the IV drip.

Pros: Those who wish for direct bloodstream delivery benefits without regular IV appointments might opt for NAD injections:

  • High Absorption Rate: Like the IV method, injections bypass the digestive system.

  • Home Convenience: Direct home delivery of treatment kits.

  • Cost-effective: Generally less expensive than the IV method.


  • Cost: While cheaper than IV, injections are costlier than oral supplements.

  • Self-administration: Some may find self-injecting daunting.

  • Needle Aversion: Like IV, not suitable for those uncomfortable with needles.
    In choosing between these methods, one must consider their comfort level, budget, and the desired frequency of treatment. Both methods have shown efficacy, but individual preferences and needs will determine the best fit.

NAD IV Therapy Research

Alcohol and Drug Addiction:

The surge in interest surrounding NAD IV therapy can be traced back to research papers published in 1961. These studies showcased how NAD IV treatment (known then as oxidized diphosphopyridine nucleotide) could effectively combat cravings and withdrawal symptoms in drug and alcohol addicts. The rate of NAD IV infusions was adjusted based on patients' reactions, ranging from 5 to 35 drops per minute. Impressively, even those who were intoxicated at the time of treatment exhibited immediate improvement. Another intriguing finding: two non-alcoholic subjects who underwent NAD IV therapy prior to consuming alcohol reported no subsequent hangovers. This could potentially explain the rising popularity of NAD IV therapy among celebrities like Justin Bieber.

Parkinson’s Disease and Depression:

There's a budding body of evidence suggesting NAD IV therapy can mitigate Parkinson’s disease symptoms. A prominent case study, sponsored by NAD Research Inc, attributes this therapeutic effect to NAD+'s ability to elevate dopamine levels. Dopamine, a neurotransmitter crucial for motor functions, is often dysregulated in Parkinson's disease. In a related vein, another study demonstrated that NADH (the reduced form of NAD+) administration, including through IV, led to improvements in depression symptoms in 93% of participants. However, it remains unclear what proportion of these subjects specifically received a NAD infusion.

Recent Research

A groundbreaking 2019 pilot study, again backed by NAD Research Inc, sought to measure plasma NAD+ concentrations post-IV NAD+ infusion. The results were surprising: plasma NAD+ levels didn't show a significant uptick until the 2-hour mark of NAD IV therapy. This delay likely indicates the swift tissue absorption and metabolism of NAD⁺ within two hours of the NAD Therapy. Notably, Dr. David Sinclair, the esteemed Harvard scientist championing NAD+ research, brought attention to this study via Twitter.

While empirical scientific research is the gold standard, anecdotal evidence on nad therapy, especially in large volumes, cannot be ignored. A few books offer insights supporting NAD IV therapy.

NAD Therapy! Too Good to Be True? by Theo Verwey:

As a practicing psychologist, Verwey claims to have treated over 6,000 patients with NAD IV therapy. He speculates a potential spectrum disorder rooted in NAD deficiency that spans symptoms from chronic fatigue and addiction to depression, stress, and more severe chronic ailments.

Addiction: the Dark Night of the Soul/Nad+: the Light of Hope by Paula Norris Mestayer:

Co-founder of NAD+ Research Inc., and spouse to Dr. Richard Mestayer, Norris Mestayer paints a vivid narrative of her 18-year experience employing NAD IV therapy. She aids her clients in transitioning away from alcohol and drugs, opining:

“Our nation confronts a staggering opioid crisis. Yet, the prevailing solution has been to administer substitute narcotics, chaining patients to prolonged regimens of methadone or Suboxone. However, we have an entirely natural alternative treatment at our disposal.”

The evidence shows both extensive clinical studies and the plethora of anecdotal accounts point towards the efficacy of NAD IV therapy in addressing alcohol and drug addiction, Parkinson’s disease, and even depression. The buzz around NAD IV therapy seems justified. Yet, as the therapeutic landscape broadens, multiple techniques for elevating NAD levels have emerged, leaving a looming question: is the NAD IV Therapy route truly the best?

NAD Therapy Side Effects and Costs

NAD therapy, especially in the form of IV therapy, has gained considerable attention for its potential therapeutic benefits in various areas, including anti-aging, brain health, and recovery from substance abuse. However, as with any treatment, there are associated risks and costs to consider.

Symptomatic Side Effects: These appear immediately after treatment.

  • Headaches - Mental Fog
  • Abdominal pain
  • Fatigue
  • Nausea
  • Diarrhea
  • Indigestion

Most of these side effects can range from mild to moderate. Nonetheless, it's crucial to contact a healthcare professional if you experience a severe side effect.

Metabolic Side Effects: These arise over time, especially for those on high-dose, prolonged treatments.

Method-specific Risks: Depending on the delivery method:

  • Vein damage and infection for NAD IV therapy and injection therapies.
  • Air embolism risk with NAD IV therapy, highlighting the importance of seeking services from qualified professionals.

Remember to undergo a thorough evaluation by your NAD provider before beginning treatments. Additionally, ensure that the laboratory supplying NAD is FDA-certified, indicating compliance with safety standards.

Average Cost of NAD Treatments

  1. NAD IV Therapy (NAD Infusions) A one-time treatment comprising NAD IV Therapy, usually combined with other active ingredients depending on desired health benefits.

    • $500-$1000 USD

  2. NAD Injections: Self-administered shots focusing on restoring NAD levels and delivering anti-aging benefits for higher energy levels and healthy brain function

    • $80-$100 USD per injection

When considering NAD therapy, weigh the potential benefits against the risks and costs. Ensure you're working with a reputable provider, and stay informed about the latest research and findings related to NAD, NAD IV Therapy, and its applications.

NAD IV Therapy vs Oral NAD Supplementation

NAD+ (nicotinamide adenine dinucleotide) plays a crucial role in several cellular processes. Its levels decline as we age, leading to potential health issues and concerns. Recent interest has surged in methods of boosting NAD+, with IV and oral routes being predominant.

IV NAD Therapy pitfalls

NAD Infusions (NAD IV Drip) have proven merit in treating drug addiction, Parkinson's', and even depression. But there is no scientific substantiation to date on its benefit for Longevity. Whether the human body and brain cells can truly benefit from NAD IV Drip is still debatable. What is undoubtedly true is that NAD IV Drip clinics are gaining in popularity. NAD IV Drip bars have been offering NAD infusions promoting it as the fountain of youth. Even celebrities such as Hailey Beiber and Joe Rogan have outwardly acknowledged their experiences with both IV NAD infusion and injections. Although the science is not yet clear on if IV NAD infusion truly does promote higher NAD levels in the body. As opposed to Oral NAD+ supplements that are proven to steadily and consistently increase NAD levels compared to IV NAD Infusion Therapy.

Oral administration of NAD+ and why Liposomal NAD is key

  • Oral administration of generic NAD active form is metabolically unstable due to the inability of NAD to survive the harsh conditions of the

  • NAD+ precursors, NR (nicotinamide riboside) and NMN (nicotinamide mononucleotide), can survive the harsh conditions of the gastrointestinal process and effectively elevate NAD+ levels when taken orally.

  • NMN, although scientifically effective, was banned by the FDA in 2022 for use as an oral supplement. Oral supplement brands selling NMN are doing so without the consent of and in direct opposition to the FDA and its safety guidelines.

  • NAD+ precursors need to be broken down and converted by the body into NAD⁺ which decreases its effectiveness compared to Liposomal NAD+.

  • Liposomal NAD+ micro-encapsulated the active form of NAD+ (nicotinamide adenine dinucleotide) bypassing the enzymatic biosynthesis associated with precursors such as NR and NMN to deliver the purest and most orally bioavailable form of NAD+ directly into the body's cells to accelerate its natural biological processes.

Consistency is Key

  • The dosage and frequency of NAD IV therapy vary across clinics due to a lack of standard, scientifically-backed dosing regimens. NAD drips, NAD IV, and NAD Infusions all mean different things with different doses depending on which medical professional is administering it.

  • Oral supplementation studies often involve consistent, daily doses, showing a consistent rise in NAD+ levels. This provides prolonged benefits of NAD+, such as

Evidence Skewed Towards Oral Supplementation

  • The anti-aging effects of NAD IV Therapy are not as extensively studied as oral supplementation.

  • Studies on Liposomal NAD and precursors have demonstrated various anti-aging benefits.

Risk-Benefit Analysis

  • The current body of research around NAD IV therapy is limited.

  • Researchers often prefer working with Oral NADdue to it being less invasive and less time-intensive than NAD IV therapy.

  • Consumers might also prefer oral NAD+ due to these factors and the added convenience.

Cost Consideration

  • NAD IV therapy and NAD Infusions are 20x-50x more expensive than oral supplementation (per serving).

  • Considering the convenience and cost-effectiveness, consumers might lean towards Liposomal NAD+.

NAD+: The Future of Daily Supplementation

Given the rising tide of the aging population, finding effective solutions for age-related chronic diseases isn't just desirable - it's imperative.

Enter NAD+, a molecule that has the medical professional community and scientists around the world buzzing with excitement.

Often labeled as the "miracle molecule", NAD+ holds promise due to its potential role in promoting cellular health. Research has shown that in animal models, NAD⁺ can combat a range of conditions associated with aging, from heart diseases and diabetes to decreased cognitive function and obesity. But the journey from laboratory Petri dishes and animal models to human treatments is riddled with challenges. The chief among these is establishing how these promising findings in animals can be translated into effective and safe treatments for humans.

Liposomal NAD+

Liposomal NAD+


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For scientists, the journey is just beginning. Deep dives into understanding NAD's biochemical mechanism are underway. By unraveling the intricacies of how NAD⁺ operates and affects metabolism, researchers hope to unlock the secrets of its potential anti-aging properties. The ultimate goal? Translating this groundbreaking science from the research bench to clinical bedside, offering hope to millions worldwide looking for improved energy levels, physical performance, and brain regeneration all in one longevity super supplement.

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