What is Berberine?

Berberine is a plant-derived compound with a long history of use in traditional Ayurvedic and Chinese health practices.

Rho’s Berberine formula uses a well-studied form, Berberine HCl, combined with a liposomal delivery system designed to support absorption.*

How Does Berberine Work?

Berberine interacts with an enzyme called AMPK, which plays a key role in supporting cellular energy balance and metabolic function.*

This interaction is associated with support for glucose metabolism, including healthy glucose uptake in cells and balanced glucose production.*

These effects may help support metabolic health, energy production, and overall cardiovascular function when combined with a healthy lifestyle.*

does Berberine

Support Metabolic Health and Glucose Balance?

Berberine is a plant compound known for its role in supporting cardiovascular health, metabolic function, and digestive health. It has also been studied for its effect on glucose metabolism.

Research suggests that berberine activates AMPK, an enzyme involved in energy regulation. AMPK activity is associated with improved glucose utilization and lipid metabolism, which may support healthy weight management when combined with diet and exercise.*

Who Can Benefit from Berberine?

Those Seeking Metabolic Support

Suitable for those looking to support overall metabolic function.*

Blood Sugar Support

Helps maintain healthy blood sugar levels already within the normal range.*

Cardiovascular Health

Supports healthy cholesterol levels and cardiovascular function.*

Women's Health

May provide nutritional support for women’s hormone-related metabolic wellness.*

Adults Focused on Healthy Aging

Offers support for metabolic wellness as part of healthy aging.*

Recommended By

Top Health Experts & Pro Athletes

Gary Brecka

Gary Brecka

world-renowned human biologist, Rho Partner

I've made Rho's NAD+ and Glutathione part of my daily routine. A powerful combo that helps support clean energy, natural detox pathways and longevity.

Dr. Amy Shah MD

Dr. Amy Shah MD

Cornell, Harvard, Columbia Trained Md, Rho Partner

I've dedicated my career to improving the health and longevity of my patients. Rho is what I recommend and take personally as a part of my holistic approach to health and longevity.

Noah Ohlsen

Noah Ohlsen

11x Crossfit Games Athlete & 2x Medalist, Rho Partner

I was honestly blown away by how fast I felt the difference in my performance and recovery. Rho’s supplements help me push harder in training and bounce back quicker than ever.

Dr. Becky Campbell MD

Dr. Becky Campbell MD

Functional Medicine Physician, Rho Partner

I’m usually picky about supplements, but with Rho’s Liposomal absorption technology, I know I’m getting unmatched effectiveness.

Ben Greenfield

Ben Greenfield

Health Consultant and NYT Best-Selling Author, Rho Partner

Rho’s collagen peptides and curcumin are a staple in my longevity stack. They help support healthy joints, skin, and cellular aging.

Lauren Fisher

Lauren Fisher

9x CrossFit Games Athlete, Rho Partner

Over my eight years competing at the CrossFit Games, supplementation has been a crucial part of my daily regimen. The purity and potency of Rho’s products are something I can trust.

Ken Rideout

Ken Rideout

World Champion Marathoner, Rho Partner

Rho is a core part of my routine because I feel the difference. Curcumin & NAD+ help me recover faster, stay sharp, and show up with intensity every day.

Dr. Mani Kukreja MD

Dr. Mani Kukreja MD

CEO of Livagewell, Rho Partner

I've dedicated my career to improving the health and longevity of my patients. Rho is what I recommend and take personally as a part of my holistic approach to health and longevity.

Kaisa Keranen

Kaisa Keranen

Movement Coach & Founder of Just Move, Rho Partner

Rho transformed how I feel, sleep, look and perform. At 40, these supplements have given me more energy, improved my sleep, skin, and taken my performance to the next level!

These individuals partner with Rho Nutrition as paid ambassadors, sharing their real routines and results.

Recommended By

Top Health Experts & Pro Athletes

Gary Brecka
Dr. Amy Shah MD
Noah Ohlsen
Dr. Becky Campbell MD
Ben Greenfield
Lauren Fisher
Ken Rideout
Dr. Mani Kukreja MD
Kaisa Keranen
Gary Brecka

Gary Brecka

world-renowned human biologist, Rho Partner

I've made Rho's NAD+ and Glutathione part of my daily routine. A powerful combo that helps support clean energy, natural detox pathways and longevity.

Dr. Amy Shah MD

Dr. Amy Shah MD

Cornell, Harvard, Columbia Trained Md, Rho Partner

I've dedicated my career to improving the health and longevity of my patients. Rho is what I recommend and take personally as a part of my holistic approach to health and longevity.

Noah Ohlsen

Noah Ohlsen

11x Crossfit Games Athlete & 2x Medalist, Rho Partner

I was honestly blown away by how fast I felt the difference in my performance and recovery. Rho’s supplements help me push harder in training and bounce back quicker than ever.

Dr. Becky Campbell MD

Dr. Becky Campbell MD

Functional Medicine Physician, Rho Partner

I’m usually picky about supplements, but with Rho’s Liposomal absorption technology, I know I’m getting unmatched effectiveness.

Ben Greenfield

Ben Greenfield

Health Consultant and NYT Best-Selling Author, Rho Partner

Rho’s collagen peptides and curcumin are a staple in my longevity stack. They help support healthy joints, skin, and cellular aging.

Lauren Fisher

Lauren Fisher

9x CrossFit Games Athlete, Rho Partner

Over my eight years competing at the CrossFit Games, supplementation has been a crucial part of my daily regimen. The purity and potency of Rho’s products are something I can trust.

Ken Rideout

Ken Rideout

World Champion Marathoner, Rho Partner

Rho is a core part of my routine because I feel the difference. Curcumin & NAD+ help me recover faster, stay sharp, and show up with intensity every day.

Dr. Mani Kukreja MD

Dr. Mani Kukreja MD

CEO of Livagewell, Rho Partner

I've dedicated my career to improving the health and longevity of my patients. Rho is what I recommend and take personally as a part of my holistic approach to health and longevity.

Kaisa Keranen

Kaisa Keranen

Movement Coach & Founder of Just Move, Rho Partner

Rho transformed how I feel, sleep, look and perform. At 40, these supplements have given me more energy, improved my sleep, skin, and taken my performance to the next level!

These individuals partner with Rho Nutrition as paid ambassadors, sharing their real routines and results.

RHO Liposomal Technology

How It Works

step 1

Encapsulation

Nutrients are enclosed within liposomes—tiny, lipid-based spheres designed to protect active ingredients.

step 2

Delivery

Liposomes transport nutrients through the digestive system, shielding them from breakdown.

step 3

Designed For High Absorption

Traditional supplements break down in digestion. Our phosphatidylcholine-based liposomes act as protective carriers, supporting absorption.

step 1

Encapsulation

Nutrients are enclosed within liposomes—tiny, lipid-based spheres designed to protect active ingredients.

step 2

Delivery

Liposomes transport nutrients through the digestive system, shielding them from breakdown.

step 3

Designed For High Absorption

Traditional supplements break down in digestion. Our phosphatidylcholine-based liposomes act as protective carriers, supporting absorption.

Nutrient

Liposome

Customer Reviews

Based on 295 reviews
81%
(240)
11%
(33)
5%
(16)
1%
(3)
1%
(3)
M
Michelle S.
This combo has helped get

This combo has helped get me focused and get back on track.

L
Loredana T.
Not sure

I don’t feel a difference

T
Tracey C.
Great addition to your morning supplement routine.

I love this product so much. Works amazingly. It’s a great addition to my morning routine of Rho products. My absolute favorite supplements, quality and taste are the best I have found.

S
Sonya Cox
One month in and loving this product!

I have noticed a change in my blood sugars, staying more consistent throughout the day! Which in turn has given me more energy. I cant wait to see if it will help loose a few pounds as well!

C
Catherine McDermott
Liposomal Berberine

Works great for me. Really curbed my appetite!

S
Sheila Temperton
Berberine

Been taking a few months now, seen a difference in energy and cravings. Will continue the product.

A
Angela Williams
Sngie

Side effects-bloating and constipation

T
Thomas Lynch
Berberine pills...mixed opinions

While many would argue over the benefits of pills versus liquids, my opinion is pills do not.offer the same.effects. Pills talent longer to breakdown and be absorbed.

L
Lori Adamson
Easily stay regular

I find that if I take this once a day after a meal I stay regular. It's the easiest way I have ever found to stay regular.

D
Debbie Walker
Not sure yet

Just started taking this product and haven’t seen any changes or differences yet . Also what’s best time to take for weight loss ?

All reviews are from verified buyers. Some customers received a discount on a future order for sharing their honest feedback. Reviews reflect the opinions and experiences of individual customers and may not be typical for all users.

Questions? We have answers!

For optimal results the recommended daily dose is 15ml, equivalent to one tablespoon. You have the flexibility to take it with or without food, directly from the teaspoon, or mixed into any beverage of your choice. You can combine Rho creatine with other Rho products in the same drink for added convenience. It can also be added into any workout shakes or drinks.

You can easily manage your subscription by navigating to the footer of our website and clicking the ‘Manage Subscription’ tab. From here you can login using the email that was used to place your order. You will be sent a one time code to your email to login with. Once in your subscription portal you have full control to cancel, modify, swap products, change shipping dates and even gift an order.

Nope! While we suggest refrigerating all Rho products for the best taste experience, refrigeration isn't mandatory. You can even take them on the go without refrigeration, making them perfect for travel.

Liposomal delivery is a technique used to help support the absorption and bioavailability of certain nutrients. It involves encapsulating the active ingredient within tiny lipid-based bubbles called liposomes. These liposomes act as protective carriers, helping the nutrient pass through the digestive system and supporting its absorption into the body.

Domestic orders typically arrive within 3-6 business days and you will receive an email with the tracking information as soon as your order leaves our warehouse in New Jersey. If you have any questions or concerns, please feel free to reach out to our team at support@rhonutrition.com and they will be happy to help.

We recommend consuming a new product consistently for a couple of months for optimal results. However, if you’re not satisfied for any reason we have a 60-day money back guarantee. Simply email support@rhonutrition.com to let us know and we will happily assist you. You can read the full Refund Policy here. 

Sunflower lecithin is often confused with sunflower oil, but the two are very different. While sunflower oil is simply the pressed oil from sunflower seeds, sunflower lecithin is a special substance extracted from these seeds that contains important nutrients called phospholipids. One key phospholipid it provides is phosphatidylcholine, which is essential for building true liposomes—tiny, protective “bubbles” that can carry nutrients into your cells more effectively. In other words, sunflower lecithin is not the same as the sunflower oil you’d use in cooking. Instead, it’s a natural, safe ingredient that helps create stable, high-quality liposome supplements to improve the delivery and absorption of vitamins and other nutrients.

Yes, at Rho Nutrition every single product undergoes a rigorous quality control process ensuring we are setting the industry standard for quality and safety. Every step of the manufacturing process is carefully documented, tested and done in a cGMP, FDA registered and allergen free facility. Every product undergoes third party testing for purity, safety, and potency.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.