TMG (trimethylglycine), also known as betaine, is a naturally occurring compound found in foods such as beets, spinach, and whole grains. In the body, it acts as a methyl donor that helps recycle homocysteine back to methionine, supporting SAMe production and overall methylation activity.* TMG also functions as a cellular osmolyte, helping cells maintain normal fluid balance and resilience under metabolic and environmental stress.*

Liposomal TMG+ encapsulates TMG inside tiny phospholipid spheres that resemble cell membranes.* This delivery system is designed to help protect TMG through the digestive tract and support efficient absorption and cellular uptake, so more of what you take is available for use by your cells compared to standard non-liposomal forms.*

Liposomal TMG+ is designed for adults looking to support healthy homocysteine metabolism, methylation pathways, and liver function.* It can also be a useful addition for individuals focused on performance, recovery, and maintaining a healthy body composition, especially when combined with a nutrient-dense diet, regular exercise, and other foundational lifestyle habits.*

TMG helps support healthy homocysteine metabolism, and homocysteine is one factor involved in cardiovascular health.*

While TMG is not intended to diagnose, treat, cure, or prevent cardiovascular disease, supporting normal homocysteine metabolism is one way to help maintain overall cardiovascular function as part of a comprehensive lifestyle approach.*

Take 6 mL (just over one teaspoon) per day, or as recommended by your healthcare practitioner.* You may take it directly by mouth or mixed in a small amount of water or your favorite beverage. Each bottle contains 30 servings and will last 30 days when used as directed.*

Liposomal TMG+ can be taken at any time of day. Many people prefer taking it in the morning, with or without food, to support daytime methylation and energy pathways.* Others choose to split the serving between morning and early afternoon. The most important factor is consistent daily use as part of your routine.*

If you take prescription medications or have a medical condition, including cardiovascular, liver, or kidney conditions, talk with your healthcare provider before using Liposomal TMG+.* TMG is often used alongside B vitamins, creatine, and other metabolic support nutrients, but your clinician can help you determine the best combination for your individual needs.*

Yes. Liposomal TMG is designed to complement other Rho formulas, NAD+, glutathione, magnesium, curcumin + resveratrol, B12, and performance-support products.* If you are using multiple supplements or have a medical condition, consult your healthcare professional to personalize your protocol.*

TMG is generally well tolerated. Some individuals may notice mild digestive changes when starting TMG-containing supplements, especially at higher intakes.* If you are sensitive, consider starting with a smaller amount and gradually increasing to the full serving as tolerated. As always, speak with your clinician if you have specific concerns or if you experience persistent discomfort.*

Yes. All Rho products are manufactured in a non-GMO, gluten-free, soy-free, dairy-free, and nut-free facility. Every batch undergoes third-party testing for identity, purity, potency, and contaminants. All Rho products are produced in a cGMP-certified, FDA-registered facility with full quality documentation.