Methylfolate (5-MTHF) is the active, bioavailable form of folate that your body can use immediately. Unlike synthetic folic acid, it does not require conversion by your body through the MTHFR enzyme. This makes it ideal for individuals who want more direct support for methylation, mood, homocysteine metabolism, cellular energy, and nervous system health.*

Methyl B12 (methylcobalamin) works synergistically with methylfolate in key methylation pathways that influence neurotransmitter production, DNA synthesis, red blood cell formation, and energy metabolism.*

Taking both together supports efficient methylation and balanced homocysteine levels.*

Each bottle contains 30 servings. When taken daily as directed, it will last 30 days.

Take 6 mL (just over one teaspoon) per day, or as recommended by your healthcare practitioner. You can take it directly from the spoon or mix it into cold water or juice.

Before opening:Store in a cool, dry place.

After opening: While its not required, some people like to refrigerate for taste and freshness.

Use within 75 days of opening.

Liposomal delivery encapsulates nutrients inside tiny phospholipid spheres that help protect them during digestion and support efficient absorption. This system helps your body utilize more of the active forms of folate and B12 where they’re needed most - at the cellular level.*

Genetic variations such as MTHFR can reduce the body’s ability to convert folic acid and standard B12 into their active forms. Because this formula provides pre-methylated nutrients (5-MTHF + methylcobalamin), it bypasses several conversion steps and may offer more consistent support for people who need help with folate and B12 metabolism.* That said, we always recommend consulting a licensed healthcare provider for any medical questions or personal guidance.

This formula supports:

• Healthy methylation*
• Cellular energy & metabolism*
• Nervous system health & cognitive function*
• Mood & emotional well-being*
• Cardiovascular & homocysteine support*

Benefits vary by individual and depend on overall health, nutritional status, and consistency of use.

Methylated B vitamins are generally well tolerated. Occasionally, some people may feel more energized than expected or notice mild changes in sleep or mood when starting methylated forms. If you are sensitive to methyl donors, consider starting with a smaller amount and increasing as tolerated, or speak with your clinician.

Yes. All Rho products are designed to work synergistically. Methylfolate and B12 pair well with glutathione, magnesium, and other daily essentials. If you take prescription medications or have a medical condition, consult your healthcare professional before starting.

Absolutely. Every batch undergoes rigorous third-party testing for identity, purity, potency, and contaminants. All Rho products are produced in a cGMP-certified, FDA-registered facility with full quality documentation.

Yes. All Rho products are manufactured in an allergen-free, non-GMO, gluten-free, soy-free, dairy-free, and nut-free facility.